significant disadvantage

However, a significant disadvantage of this system is that, due to its small size, the auxiliary memory is permanently dedicated to the storage of the low resolution foreground color information.
US Pat. 4757309

Another significant disadvantage of conventional single optical fiber ring communications systems is that the entire loop goes down when one fiber becomes inoperative.
US Pat. 5535035

The significant disadvantage in its network scalablity is primarily caused by the (N-1) number of ports required in each node of the network, since the number of ports must be changed in every previously existing node in the network when the number N of nodes is increased in the network.
US Pat. 6721335

This functional rigidity limits the application of a particular graphics display system and is a significant disadvantage, particularly in the general purpose display system field.
US Pat. 4951229

But this approach has the significant disadvantage that each instantiation of such a process model is executed by the WFMS with identical execution priority characteristics.
US Pat. 6976257